The show centers on the antisocial actions of an alcoholic mouse known as "Mouse Fitzgerald", "Fitz," "Butch," or simply "Mouse". The show was created by Matt Maiellaro, co-creator of Aqua Teen Hunger Force, and produced by Williams Street for Adult Swim. The series is animated in the style of crude drawings with limited motion. The usage of firearms, alcohol consumption, and indifferent homicidal acts are common activities of the sociopathic lead character Mouse Fitzgerald.

The plot revolves around a bizarre conspiracy which is constantly building on itself and taking seemingly nonsensical twists and turns. At times the narrative becomes obfuscated or nonlinear, but it simultaneously reveals connections that hint at an objective story. Clues and secret messages are hidden throughout each episode, including the credits. Creator Matt Maiellaro has indicated that the development of 12 oz. Mouse was influenced in part by surrealistic films and the Theatre of the Absurd, such as those by director David Lynch.

The series concluded its initial run on Adult Swim on December 18, 2006 with its twentieth episode. However, the plot was left unresolved. In February 2007, production began on additional episodes for internet distribution on Adult Swim Video. The first online episode premiered May 16, 2007.

• Adult Swim site for 12 oz. Mouse
• 12. oz Mouse Central - Official fansite from the creators of Aqua Teen Central and Perfect Hair Central
• AdultSwim.co.uk - Watch 12 oz. Mouse on Adult Swim UK
• IMDb entry for 12 oz. Mouse
• Interview with 12 oz. Mouse creator Matt Maiellaro

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