They eventually end up crash landing on Earth in the city of Chicago. There they meet a charming female mechanic named Charlene "Charley" Davidson and discover that the Plutarkians have come to Earth to exploit its natural resources. The Plutarkians are a smelly humanoid fish-like race who exploit other planets for natural resources because they have wasted all of their own. The Plutarkians have already caused massive devastation on Mars that resulted in the death of most of the Martian mice population and the near-destruction of Martian flora and fauna. The biker mice discover that Chicago's leading industrialist, Lawrence Limburger, is actually a Plutarkian who disguises himself as a human. Limburger enlists the aid of villains like the sadistic mad scientist Dr. Karbunkle and the idiotic Greasepit to help him steal Earth's natural resources and send them to Plutark. However, he witnesses the eventual foiling of his plans (and the destruction of his building) by the biker mice at the end of each episode.

The episode would always start out with a setup for a situation like Greasepit setting up a digging machine, the mice showing up parodying a song, laughing or cracking jokes, them dominating for a short while, being in seeming danger, and starting with the introduction.

The new 26 episode series began airing in the UK on Toonattik on GMTV (now known at weekends as CITV) on August 26, 2006. The third episode was the highest rated show on the Channel on its launch weekend. The show has been GMTV's highest rated show of the autumn season. On two of the weeks to November 11, the show looks to have been the UK's highest rated kids show on any channel.

CITV on ITV2 re-ran the original 1990s series at 07.55 Monday to Friday for a 10 week strip from early September 2006. They will be played again on ITV2 at 08.25 Monday to Friday for 10 weeks from March 27, 2007.

The series launched in Finland on MTV3 and in Australia on Channel Ten in October 2006. The series launched in the Nordics/Scandinavia on Cartoon Network on March 5, 2007. Many other countries will see the new series in the fall of 2007. A full length 13 minute introductory trailer to the new series is on Google Video. Trailers for each new episode in the UK, Finland and Australia appear on YouTube each week[1]

Plans for the new series release in the United States have not been announced, reportedly due to difficulty finding a network to air it. Retro Biker Mice from Mars related items are currently for sale on numerous auction sites. Prices of the rarer 1990s merchandise items on eBay in the UK are commanding collector's prices.

Merchandise based on the new series was launched in the UK from August 2006 and features with online retailers such as Amazon UK. It is in full-retail distribution in the UK and Finland. The action figure line was already the seventh best selling property in the category in The UK by November 2007.

A racing video game based on the series was published by Konami for the Super NES in 1994. It is reminiscent of Rock N' Roll Racing. PS2 & DS games from The GameFactory released a PS2 game in the UK on November 10, 2006. It will be launched elsewhere in conjunction with Territory broadcast air dates for the new series.

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