Mallory (Bonamy) is the head of an elite government-run strike force dedicated to combating the supernatural. Her team includes the drag queen Vena Cava (Ribier), an explosives expert; a mute, pre-teen telepath capable of possessing others named Talking Tina (Barès); and an armed governmental agent named Durand (Thierry Perkins-Lyautey). They are dispatched to protect a convent from an assault by a pack of undead monsters when they are attacked by an unknown assailant. The battle leaves Durand dead, Vena Cava injured, and Tina in a coma. Simultaneously, the newly-elected pope (Spielvogel) is kidnapped by strange, masked attackers who resist the bullets of the pope's bodyguards. Mallory is approached to rescue the pope, a job she reluctantly accepts when she realizes there may be a connection between her team's assailant and the pope's kidnappers.

Tracking the kidnappers to a pocket dimension containing an entire village that had vanished off the map several years earlier, Mallory and her team are joined by Père Carras (Collado), a priest trained in the martial arts and one of the bodyguards present at the time of the pope's kidnapping. Their search for the pope eventually leads to a centuries-old vampire named Lady Valentine (Vargas) and her mission to summon Abaddon, a fallen angel that will cover the world in darkness.

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