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• Nailed (2009) (post-production) .... Rep. Pam Hendrickson
• Where the Wild Things Are (2009) (post-production)
• Untitled Nicole Holofcener Project (2009) (post-production)
• The Soloist(2008) (post-production)
• Genova(2008)
• Synecdoche, New York(2008) .... Adele Lack
• Hamlet 2 (2008) .... Brie Marschz
• What Just Happened?(2008) .... Lou Tarnow
• Into the Wild(2007) .... Jan Burres
• An American Crime(2007) .... Gertrude Baniszewski
• Friends with Money (2006) .... Christine
• Capote (2005) .... Nelle Harper Lee
• The 40 Year Old Virgin (2005) .... Trish
• The Interpreter(2005) .... Dot Woods
• The Ballad of Jack and Rose (2005) .... Kathleen
• S1m0ne (2002) .... Elaine Christian
• Full Frontal (2002) .... Lee
• Death to Smoochy (2002) .... Nora Wells
• [[ Lovely & Amazing (2001) .... Michelle Marks
• [[ American Arts & Culture Presents John Horatio Malkovich 'Dance of Despair & Disillusionment' (2000) (V) (uncredited) .... Maxine
• Simpatico(1999) .... Cecilia
• [[ Being John Malkovich (1999) .... Maxine Lund
• 8MM (1999) .... Amy Welles
• Your Friends & Neighbors(1998) .... Terri
• Out of Sight (1998) .... Adele
• The Real Blonde (1997) .... Mary
• If These Walls Could Talk(1996) (TV) .... Becky Donnelly (segment '1952')
• Box of Moon Light (1996) .... Floatie Dupre
• Boys (1996) .... Jilly
• Heroine of Hell(1996) (TV) .... Magda
• Walking and Talking (1996) .... Amelia
• The Destiny of Marty Fine(1996) .... Lena
• Living in Oblivion(1995) .... Nicole Springer
• Journeys North(1994) (TV) .... Magda
• The Cemetery Club(1993) (uncredited) .... Esther's Daughter
• The Gun in Betty Lou's Handbag(1992) .... Suzanne
• Seinfeld.... Nina (1 episode, 1992)
• Johnny Suede(1991) .... Yvonne
• Switch (1991) .... Steve's Secretary
• Arduous Moon(1990)
• CBS Summer Playhouse .... Jan Engle (1 episode, 1989)
• Survival Quest (1989) .... Cheryl
• Knightwatch .... Rebecca (1 episode, 1989)
• Catchfire(1989) .... Trucker's girl
• Ohara(1987) TV series .... Lt. Cricket Sideris (unknown episodes, 1987)
• L.A. Law.... Waitress (1 episode, 1986)
• The Alan King Show (1986) (TV) .... Abby
• About Last Night... (1986) .... Cocktail Waitress
• The Education of Allison Tate (1986) .... Linda Kellogg

Attended a Catholic high school, Monsignor Edward Pace High School, Miami, Florida. Graduated from Wheaton College in Norton, Massachusetts in 1983.

Graduated from Immaculate Conception in Hialeah, Florida

Grew up in Hialeah, Florida.

Son Clyde is born. [1999]

Sister-in-law of Kieran Mulroney.

Has been close friends with Brad Pitt since they both starred in 1991's Johnny Suede (1991) together, and they often attend each other's movie premieres.

Older sister of Elizabeth Keener.

Was member of the dramatic jury at the Sundance Film Festival in 1997.

Of Irish and Lebanese descent.

Nominated for 2 Oscars. Another 13 wins & 23 nominations