Is the youngest of 6 children.

Released her memoir, "My Horizontal Life: A Collection of One-Night Stands" in June, 2005.

Friend of Jenny McCarthy.

Has a nephew, Teddy.

Her mother died of cancer.

Chelsea Lately

Steam (2007) .... Jacky

In the Motherhood .... Heather (1 episode, 2007)

30 Most Outrageous Celebrity Feuds (2006) (TV)

Reno 911! .... 'Pinky' the Drunk Driver (1 episode, 2006)

Cattle Call (2006) .... Nikita

Dirty Famous (2005) (TV) .... Missy Klein

Totally High (2005) TV series

The Bernie Mac Show .... Doris Flynt (2 episodes, 2004)

Girls Behaving Badly (2003) TV series (unknown episodes)

My Wife and Kids .... Nurse Amy (1 episode, 2002)

The Practice .... Callie (1 episode, 2002)

The Plotters (2001) (TV) .... Ann

Spy TV .... Various (1 episode, 2001)

Handler was born in the suburban town of Livingston, New Jersey in the USA.[3] The youngest of six children, she was raised Jewish by her Mormon mother, Sylvia, and Jewish father, Melvin. Handler's mother passed away from cancer.

Handler has performed nationwide as a stand-up comedian, appeared as a regular on the Oxygen Network series Girls Behaving Badly and on other shows, including Weekends at the D.L., The Bernie Mac Show and The Practice. She is a regular commentator on E! and Scarborough Country as well as a correspondent on The Tonight Show. She was a guest on Red Eye w/ Greg Gutfeld and The View, co-hosted on The View on August 2, 2007 and again on September 5, 2008 — and hosts her own late night talk show on E! titled Chelsea Lately.

Handler has authored two books on the New York Times Best Seller List. Handler wrote My Horizontal Life: A Collection of One-Night Stands (ISBN 1582346186 ) as her memoir. Handler also wrote Are You There, Vodka? It's Me, Chelsea (ISBN 0061173398), a collection of humorous essays. Are You There, Vodka hit the NYTimes non-fiction best seller list on May 11, 2008 and has already had a print run of 270,000+.

In 2007, Handler performed with the Hour Stand-Up Comedy Tour across the U.S.. Her stand-up has been televised on Vh1's Love Lounge, Comedy Central's Premium Blend, and HBO's broadcast of the Aspen Comedy Festival. Chelsea Handler was the host of the highly anticipated Fox show "On The Lot." The show, produced by Steven Spielberg and Mark Burnett, is a competition for aspiring filmmakers who are vying for a chance at stardom. She was replaced after one episode by former Robin & Company entertainment anchor, Adrianna Costa.

In July 2007, Handler began starring on her own half an hour late-night comedy series on E! titled Chelsea Lately. This series places Handler against a slew of male-dominated talk shows, taking both a female approach and adding a considerable amount of sarcasm to the format. On the show's 100th episode, Chelsea revealed to viewers that E! had picked up Chelsea Lately for another 150 episodes. The show has proved itself a hit and averaged more than half a million viewers since its premiere (much more than the average for a late night cable program) and has clips on Youtube with more than a million viewers