A sequel to Crank, titled Crank 2: High Voltage has been confirmed by the writers and directors Brian Taylor and Mark Neveldine. In Crank 2, Chelios will face a Chinese mobster who has stolen his nearly indestructible heart and replaced it with a battery-powered heart that requires regular jolts of electricity to keep working.

Lionsgate Films will handle North American distribution of the film, while Lakeshore Entertainment will handle international distribution. Filming should start in April 2008. The writers and directors confirmed there will be more sex and violence.