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• In 1993, Messing won praise for her acting in the pre-Broadway workshop production of Tony Kushner's much-lauded play Angels in America: Perestroika. Consequently, she appeared in several episodes (running from 1994 to 1995) of the award-winning television series NYPD Blue.
• In 1995, Messing made her film debut with a supporting role in A Walk in the Clouds, a love story directed by Alfonso Arau. This exposure led the Fox network to make her the co-star of the television sitcom, Ned and Stacey. The series lasted for two seasons, from 1995 to 1997. Messing appeared as Jerry Seinfeld's date in two episodes of the hit television show Seinfeld: "The Wait Out" in 1996 and "The Yada Yada" in 1997. Messing turned down a starring role in another television sitcom to appear in Donald Margulies's two-character play Collected Stories, which opened at the Off-Broadway Manhattan Theater Club in 1997.
• In 1998, Messing had a lead role as the bio-anthropologist "Sloan Parker" on ABC's dramatic science fiction television series Prey. Meanwhile, Messing's agent had approached her with the pilot script for the television show Will & Grace. Messing was inclined to take some time off, but the pilot for Will & Grace intrigued her, and she received the role of Grace Adler, beating out Nicollette Sheridan (Knots Landing, Desperate Housewives), who later guest starred on the show as a romantic rival of Grace's. Will & Grace became a big ratings success, and Messing gained renown. A lot of Messing's personal characteristics--her red hair, enormous feet, wide teeth and Jewish ancestry--were ripe, fertile fodder for the shows writers. And it help to cement Messing as an icon.
• In 2002, she was named one of the "50 Most Beautiful People in the World" by People Magazine. TV Guide picked her as its "Best Dressed Woman" in 2003. This was ironic because on "Will and Grace," one of the running jokes on the show is her character's remarkably poor fashion sense. Messing was personally picked by director Woody Allen for a small role in his 1998 film Hollywood Ending. Her big-screen roles since include a happily married but ill-fated wife in the supernatural thriller The Mothman Prophecies (2002) and a supporting role in Along Came Polly (2004).
• The Wedding Date (2005) was Messing's first leading role in a high-profile film. It received mixed reviews but performed fairly well at the box office. Messing was featured as a judge on the season finale of the second season of Bravo's hit reality show, Project Runway. In 2007, she is scheduled to appear in a new TV mini-series called The Starter Wife. Her combination of beauty and a talent for physical comedy have led some critics to compare her to Lucille Ball.

• Messing met her husband, Daniel Zelman (an actor and screenwriter), on their first day as graduate students at NYU. The two were married on September 3, 2000, and live in New York City. On April 7, 2004, Messing gave birth to their son, Roman Walker Zelman.[citation needed]

According to Star Magazine, Messing recently moved back to New York from LA.

• 1998-2006: Will & Grace as Grace Adler
• 2007-Present: Starter Wife as Molly Kagan

• 1995: A Walk in the Clouds as Betty Sutton
• 1997: McHale's Navy as Lt. Penelope Carpenter
• 2002: The Mothman Prophecies as Mary Klein
• 2002: Hollywood Ending as Lori Fox
• 2004: Along Came Polly as Lisa Kramer
• 2004: Garfield as Arlene (voice)
• 2005: The Wedding Date as Kat Ellis
• 2006: Open Season as Park Ranger Beth (voice)
• 2007: Lucky You as Suzanne

• Wikipedia: Debra Messing