Dr. Stephen Strange was one of the most gifted surgeons in medicine. One night, he notices Baron Mordo and his allies slay a monster. The next day, he is visited by the hospital's administrator Oliver who states that Dr. Gina Atwater has problems with him. He also speaks with Dr. Atwater when it comes to a child who is among the many that has suffered from dangerous nightmares. Stephen thinks back to when his sister April had a headache related to the ones the children have been having.

While driving home, he sees the vision of a man with a burning head and gets into a car crash. As a result, his hands were left shattered and useless after he awakens 3 days later. He sees the report of his injuries shown by Dr. Atwater. Spending his fortune in pursuit of a way to fix his fractured body on the advice of Oliver, the dejected doctor believed all was lost until his suicide attempt is thwarted by Wong who recommends the Ancient One to offer him hope and healing in Tibet.

Making his way to the Ancient One's temple, Wong takes him to the Ancient One. Wong joins up with Baron Mordo and the others when it came to slaying Shadowhounds. Stephen begins his training as the Ancient One is told by Wong and Baron Mordo that they have lost some of their own. After day one, he remembers when he is April's doctor. After day two, Stephen is considering giving up and departs. He then flashbacks to when he does medical work on April which fails. The Ancient One then appears in Stephen's mind. This convinces Stephen to return to his training.

The Ancient One detects two Chinous and informs Baron Mordo who leads two teams to take them on. Stephen continues his training and takes in some of the Ancient One's wisdoms. Baron Mordo's team continues to fight the Chinous as two of his teammates establish a containment spell which fails as the Chinou is vanquished. The second one also wounded some of the team and is vanquished by Baron Mordo. Later, the Ancient One mourns the loss of his disciples and orders Baron Mordo to train Doctor Strange. Baron Mordo spars with Stephen which ends up getting intense. Baron Mordo retaliates after being deflected, but Wong intervenes. Wong tells Stephen that he will be taking over his training for Mordo.

Stephen then follows the Ancient One, Wong, Baron Mordo, and others to the Sanctum Sanctorum and ends up in it's nexus. The Ancient One then tells Stephen about Dormammu. Stephen then remembers his features and is using children's dreams to enter Earth. Doctor Strange returns to the hospital to find out how widespread this is and to attempt to wake them. He awakens patient after patient to prevent Dormammu from entering Earth. Baron Mordo enters a child's dream and makes a deal with Dormammu. Dormammu takes over the minds of the remaining children as Baron Mordo attacks Doctor Strange. Wong manages to save him.

When a swarm of Wing Marks attack, they kill off the Ancient One's followers. The Ancient One is weakened taking them out as Baron Mordo arrives to attack the Ancient One. Doctor Strange and Wong arrive and find the Ancient One dead. Wong gives Doctor Strange the Eye of Agamotto since it is Doctor Strange's destiny. Doctor Strange and Wong confront Baron Mordo. As Wong fights Baron Mordo, he is wounded in battle, but Mordo is repelled by Doctor Strange. Doctor Strange then fights Baron Mordo as Dormammu begins his emergence. Dormammu then devours Baron Mordo and steals the Eye of Agamotto as he makes his way to the Sanctum Sanctorum. Doctor Strange confronts Dormammu who begins to overwhelm Doctor Strange as he unleashes his monsters around the world. With advice from Wong, Doctor Strange absorbs the pure magic to vanquish Dormammu (Wong wasn't expecting Doctor Strgange to absorb Dormammu). Wong tells Doctor Strange that they will have a lot of adventures together.

Doctor Strange visits his sister's grave and is told by Wong that they have new prospects for Strange to date. One of the first of these is one known as Clea.