Then, after cancellation, reruns aired on Cartoon Network until March 8, 2003. Bruce Timm, best known as a major principal of the DC animated universe, originally intended it to be a straightforward superhero action-adventure cartoon with comic overtones, but executive producer Steven Spielberg asked series producer/writer Tom Ruegger and the Animaniacs team to turn Freakazoid! into a flat-out comedy.

The show chronicles the adventures of the title character, Freakazoid, a manic, insane superhero who battles with a vast array of super villains. The show also features mini-episodes of adventures of other bizarre superheros.

Freakazoid! makes frequent use of stock footage which is often gratuitous and nonsensical, including the peaceful scene of a field of flowers ("Relax-O-Vision"), numerous people screaming ("Scream-O-Vision"), traditionally dressed Bavarians dancing and slapping each other, a man being shot in the belly with a cannonball and a man wrestling a bear.

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