Full House is set in San Francisco, where Danny Tanner is left to raise his three young daughters D.J., Stephanie, and Michelle following the death of his wife, Pam. In Season 8 episode Under the Influence, it was revealed that she had died in a car accident caused by a drunk driver.

Danny recruits his childhood friend Joey Gladstone and Pam's younger brother Jesse Katsopolis to live with the family and help Danny with the three girls. Many of the show's exploits revolve around the idea of three "swinging" bachelors trying to rein in the precocious antics of three girls, who frequently get the best of them. As is the case with many sitcoms, Danny's daughters ignore the rules, only to learn their lesson afterward. The episodes usually end with a hug or kiss and with the girls sometimes admitting their wrongs and working out a compromise with their father, Joey or Jesse. There is always a talk towards the end of the show.

At the beginning of the series, Danny was a sportscaster for a local TV station. He later becomes the co-host of the morning talk show Wake Up, San Francisco. Although Joey and Jesse partake in several occupations, they are primarily a stand-up comedian and musician, respectively.

Jesse later marries Rebecca Donaldson, Danny's co-host on Wake Up, San Francisco. The couple have twin boys, Nicky and Alex. Despite Jesse being married with new children of his own, he continues to live in the Tanner household.

The girls grow up as the series progresses, and various (boy)friends are introduced, notably Steve Hale, D.J.'s steady boyfriend for Seasons 6 & 7. They later break up, though in the final episode, Steve returns to escort D.J. to her senior prom.

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