Trevor Holden has just witnessed his boyfriend Darrell overdose on heroin--again. And as his oldest friend, Trevor feels a responsibility to help Darrell in his latest attempt at sobriety, much to the dismay of his own best friends Jake and Andie. But, when Darrell starts using again Trevor is finally ready to call it quits. And just when he does, he meets the ever so charming Ephram. As Trevor's relationship with Ephram quickly progresses, it starts to put a strain on his friendships with Jake and Andie. Jake, the self-proclaimed sex-addict, is starting to worry a little bit about his past catching up with him, namely in the form of HIV. And Andie, who drunkenly ends her sexual dry spell with a one-night stand, realizes that Jake might have less to worry about than she does. Meanwhile, Ephram accepts a job thousands of miles away in New York City, and he wants Trevor to go with him. Now, what started out as Trevor's own personal existential journey, turns into a path that will lead everyone to what is most important: themselves.