The addict(s) featured on the show receive an offer of a 90-day treatment plan at one of a number of rehabilitation facilities featured on the series. As in real life, not all interventions featured on Intervention end well. Some addicts have walked out of the intervention and refused to go to the treatment facility; others have agreed to get treatment only to leave treatment early due to rule violations, behavior problems, or a general desire not to be in attendance any more. Some addicts who leave early go to prison or enter another facility to continue treatment; many do not.

Occasionally, during the filming of an episode, the plight of another addict in the featured addict's circle becomes apparent, and the show often makes additional plans to help the other addict find treatment as well. The success rate of these mini-interventions parallels the main interventions' success rates.

In situations where the family/friends/other members of the addict's circle have become co-dependents or are otherwise traumatized by the addict's behavior, the interventionist usually recommends that the entire family seek some form of counseling to enable them to move on with their own lives. This has led to some very happy family reunions (Coley, a serious meth addict, got clean while his family went through counseling, and his marriage to wife Francine was saved by the intervention), but has also led to complete dissolution of relationships (Leslie, a suburban housewife alcoholic, went through court-ordered rehab while her family received counseling at the Betty Ford Clinic; after both treatment programs ended, Leslie and her husband finalized their divorce).

Each episode ends with a series of black screens, upon which appear a short narrative discussing the addicts and their progress since the intervention (including a sobriety date, if known), followed by a screen that invites viewers to find out more information on addiction and recovery at the show's official website, InterventionTV.com. The black screens are updated with new information each time the show is re-aired on A&E, and some video updates are made available on the show's official website. Occasionally, a black screen update documents an outreach to the addict from fans of the series. The black screen update for drug addicted siblings Brooks and Ian's follow-up episode that re-aired in early 2008 indicated that Brooks had met and married a fan of the show in 2007. At the end of the original episode featuring alcoholic banker and bar brawler Jacob, he stated that he was planning to enroll in college for the upcoming semester; the black screen update for his episode that re-aired in early 2008 indicated that a fan of the series had contacted the producers after the show's airing and offered to pay for Jacob's college education.

The "cast" for each episode is primarily the addict and his/her family members, circle of friends, and more. The other regular cast member in each episode is the interventionist, whose job it is to conduct the intervention. The show features four specialists:

• Jeff VanVonderen, a former pastor and alcoholic who became a full-time interventionist to help families through their moral and social issues involved with addiction.
• Candy Finnigan, a former addict who became an interventionist to help women work through their addictive issues.
• Ken Seeley, a former meth addict who founded Intervention-911, a service specializing not just in interventions but in also finding appropriate treatment centers for each kind of addict.
• Tara Fields, a Ph.D with a degree in psychology who is also a licensed marriage counselor and family therapist.

Jenn Berman, a Psy.D with a degree in psychology, made a single appearance in the episode featuring meth addict Amy and anorexic/bulimic Annie; she was the interventionist for Annie.

In conjunction with interventions that involve strong drug addictions where sudden withdrawal of the drug can be dangerous, a nurse travels with the addict to the rehab center, providing medical assistance to keep the addict from suffering during the journey. Patients with addictions that could cause serious risk to their health upon cessation of the substance abuse will usually spend 1-2 weeks in a detox facility before entering the rehab phase of their recovery.

Most episodes feature "everyday" people struggling with their addictions, but entertainment professionals have also been featured.

• Chuckie Negron, the son of Three Dog Night vocalist Chuck Negron, was featured in a Season Two episode as he battled heroin addiction.
• Vanessa Marquez, a supporting actress on the first three seasons of ER, appeared in a Season One episode suffering from a compulsive-shopping disorder.
• Travis Meeks, lead singer of the popular Alternative rock band Days of the New, appeared in a Season One episode focusing on his methamphetamine addiction.
• Antwahn Nance, a 6'10" former NBA power forward for the LA Clippers, was featured in Season Two as he ended up homeless due to his crack cocaine addiction.
• Tressa Thompson, a women's shot put champion whose Olympic dreams were crushed by her methamphetamine drug abuse, was featured in Season Two.
• Chad Gerlach, a member of the Postal Service Pro Cycling Team now living on the streets and smoking crack cocaine was featured in Season Five.

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