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Jake Foley is a computer technician for the NSA who secretly longs for a chance to work on the field. Circumstance puts him in a top secret laboratory, in the middle of a shootout between security guards and a saboteur. During the battle, a vial containing an experimental serum explodes, covering Jake with shrapnel. But it turns out that the serum is actually nanomites, microscopic submachines that heal his injuries and alter his body. Upon discovering his new mind-boggling powers, Jake begins to operate at an atomic level, possessing superhuman strength, lightning-fast speed, heightened hearing, magnified vision and the ability to communicate telepathically with computers. The NSA soon realizes Jake is an untested asset and forms a Special Ops team with him at its core. As Jake finally realizes his dream of being of being a field operative, he must also contend with the return of would-be girlfriend Sarah Heywood, who is involved in a Congressional investigation which threatens to expose his operation.

In the UK all the episodes were played out on Sky One. The series is currently being aired on HDnet on Thursdays at 10:00pm EST and has aired internationally. It also began airing on The Sci Fi Channel on January 5, 2007.

The series revolved around a computer expert, Jake Foley, who works for the U.S. government's National Security Agency (NSA) and was accidentally infected by nanobots which give him superhuman powers. He is able to control technology with his brain, making him "the ultimate human upgrade" according to the show's introduction. Jake was thus a combination of Spider Man and The Six Million Dollar Man.

• Jake 2.0 fan site
• Javier Grillo-Marxuach Interview

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