Watch Jodi Lyn O'Keefe Online

O'Keefe was born in Cliffwood Beach, New Jersey; the daughter of Noreen (née Alexandria), a homemaker, and Jack O'Keefe, a director of labor relations for a pharmaceutical company.[1] She has Irish, Czech, Austrian, Polish and Swedish ancestry.[2] When she was a child, the youngest of three sisters, she had a bowl haircut and was self-described as a "dork". Her older sister was a model and she decided that she wanted to do the same. She did, and says the modelling job brought her more confidence and more friends. She attended a Catholic school and grew from being the shortest in the class to the tallest (at 5 feet 8 inches (1.73 m)). Since leaving she has grown more and now stands at 5 feet 10 inches (1.78 m).

Midway through her junior year high school she left school to star on the soap opera Another World, playing Marguerite “Maggie” Cory. She then got a role on Nash Bridges, playing Cassidy, the daughter of Don Johnson’s title character. She and her mother moved to Hollywood, so Jodi completed her schooling by mail.

She made her big screen debut in 1998 in Halloween H20: 20 Years Later and later starred in such films as The Crow: Salvation, Whatever It Takes and Devil In The Flesh 2. She hit the spotlight when she portrayed a conceited and popular high school girl Taylor Vaughan in the teen flick, She's All That (1999) alongside Freddie Prinze Jr and Rachael Leigh Cook. When asked if it was hard to play such a character, Jodi replied, “Everybody knew a Taylor Vaughan in high school. Working in show business, you meet girls like that everyday.”

Jodi kept on filming both movies and Nash Bridges until the series ended in 2001. Later films have been Out For Blood where she played a vampire named Layla Simmons and Venice Underground. In 2005, she appeared for three episodes in the first season of Boston Legal.

O'Keefe was also in 3 Doors Down's video "Let Me Go", 2005, alongside Jesse Metcalfe of Desperate Housewives. She joined the cast of Prison Break in 2007.

She also appeared in episodes of the television series Charmed and Two and a Half Men.

Jodi Lyn O'Keefe has been having relationships with actor John Cusack. They were both photographed playing on a California beach, but snappers failed to recognize Cusack's "She's All That" pal