Born into an Italian-American family, he made his acting debut in the 1969 stage production of Hair. Joe attended Morton East High School in Cicero, Illinois (home of Al Capone) and received much inspiration for acting from this small town with lots of character. He graduated with a degree in acting from the Goodman School of Drama in 1969. Mantegna has been married to the former Arlene Vrhel since December 3, 1975. They have two children of whom one - their daughter Mia - is autistic; the other, Gina, has just finished an upcoming movie alongside her father. He debuted on Broadway in Working (1978). He also helped write Bleacher Bums, an award-winning play, which was first performed at Chicago's Organic Theater. He won a Tony award for his portrayal of Richard Roma in David Mamet's play Glengarry Glen Ross. He made his feature film debut in Medusa Challenger (1977). He played womanizing dentist Bruce Fleckstein in Compromising Positions (1985). Other early movies include co-starring roles in The Money Pit (1986), Weeds (1987) and Suspect (1987). He also starred in the critically acclaimed movies House of Games (1987) and Things Change (1988), for which he and co-star, the late Don Ameche, both received the Best Actor Award at the Venice Film Festival. In 1991 he starred in the highly praised police thriller Homicide. A highly versatile actor, Mantegna has played a wide range of roles, from the comic - as a fed up shock jock in Airheads and the hilariously inept kidnapper from Baby's Day Out to the dramatic, in roles such as Daysor Joey Zasa, a treacherous mobster in The Godfather Part III. Mantegna also has a recurring role in the animated series The Simpsons as the voice of mob boss Anthony "Fat Tony" D'Amico. He insists on voicing the character every time he appears, no matter how little dialogue he has. To quote: "If Fat Tony sneezes I want to be there". He received the Lifetime Achievement Award on April 26, 2004, at the Los Angeles Italian Film Festival.

• 2007: The Simpsons Movie
• 2005: Edmond
• 2005: Nine Lives as Richard
• 2004: This Old Cub as Narrator
• 2000: More Dogs Than Bones as De Salvo
• 1999: Liberty Heights as Nate
• 1998: Jerry and Tom as Tom
• 1998: The Wonderful Ice Cream Suit asGomez
• 1996: Thinner as Richie Ginelli
• 1994: Baby's Day Out as Eddie the kidnapper
• 1994: Airheads
• 1993: Body of Evidence
• 1993: Searching for Bobby Fischer as Fred Waitzkin
• 1991: Homicide as Detective Bobby Gold
• 1991: Bugsy as George Raft
• 1990: Alice
• 1990: The Godfather Part III as Joey Zasa
• 1987: House of Games as Mike
• 1987: Suspect
• 1986: The Money Pit
• 1986: Three Amigos as Harry Flugleman

• 2007: Starter Wife as Lou Manahan
• 1998: The Rat Pack (made-for-TV movie) as Dean Martin
• 1989: Simpsons, voice Fat Tony, Springfield's mob boss
• Joan of Arcadia series as Will Girardi, Arcadia's police chief and Joan's father
• 1991:Saturday Night Live, the original Bill Swerski's Superfans sketch as Bill Swerski
• 1993:Frasier as Derek Mann in the episode "I Hate Frasier Crane"

• Wikipedia: Joe Mantegna