Karin is the protagonist of the series. Her name literally means "The Flower Bell of the Flower Garden," with the "Flower Garden" as her surname and "Flower Bell" as her given name. Karin used to live with her aunt because her parents died a long time ago, but she moved in with Kazune and Himeka after they found out about her goddess powers. She is an outgoing person, even though she does bad in school and sticks up for her friends. She is in 8th grade. She is 13 years old with a cat named Shii-chan. The ring Karin originally thought was her mother's ring allows her to borrow godly power. Her ring is silver and has the power of the goddess Athena (Aphrodite in Chu). It is later revealed in the later volumes of the manga that Karin is actually Kazuto Kujyou's wife, Suzuka Kujyou, (Suzuka is Karin backwards, since suzu is another way to read the character rin), which was stated in Volume 7 that Karin was returned to an infant by Kazuto Kujou.

Kazune is the main male protagonist. His ring has the power of Apollo Greek god of sun (in the sequel, he has a different ring with the power of Uranus). He is in 8th grade. While he acts cool during much of the story, Himeka states that in the past, he was weak and cried frequently, only becoming his present self when he turned ten years old, after knowing who he was. While Himeka loves bugs, Kazune hates and fears them; in Kamichama Karin, Himeka reveals that Kazune's fear of bugs developed when he and Himeka ran into a giant bug when he was little (which, ironically, was Karin in a bug suit). Even though he is a clone of professor Kazuto Kujyou, he is incomplete and passes out after transforming in god form. He often speaks to Karin in a way that she deems sexist, talking about things like the inherent stupidity or weakness of girls (this is used against him in Chu when Jin calls him a 'girly boy') Kazune is in love with Karin (and tells Michiru such), and has known since the age of ten that Karin is his wife, Suzuka. He himself is the clone of his "father". The older Kazune, Kazuto, put his reseach in Himeka, and then split them in half to protect his work from his former partner, Karasuma Kirihiko. In Chu, Karin's and his son, Suzune come from the future. He warns them that Kazune goes missing in the future , and later it is discoved that he actually died soon after Suzune was born.

Himeka is Karin's friend and Kazune's "cousin". She is also Suzune's "sister" due to the fact that she is the child of Suzuka and Kazuto. Originally she contained Kazuto's god reseach data, she was then split into two by Kirihiko attempting to steal the research data. One half lives with Kazune, while the other lives with the Karasumas. When one Himeka becomes stronger, the other becomes weaker. Since she was a young girl, she has always defended Kazune, who was a bit of a crybaby when they were little. She loves bugs and is a good cook. She is in 8th grade. Like Karin, she does poorly in school. It is later revealed that she is Kazuto and Suzuka's daughter. She tells Karin at one point that while she has a strong affection for Kazune, it is not necessarily a romantic attachment, as Kazune is "kind of like a brother and kind of like a dad" to Himeka (referencing Kazune's identity as a clone of Himeka's father). She also witnessed Kazune and Karin kissing in the anime. Later in the series, Kazune says that Himeka is his daughter (along with Karin in Kamichama Karin 7).

Kirio is the main antagonist. He and Kirika are adopted by Kirihiko while they were children. He is the student council president of Sakuragaoka Academy. He tests the protagonists and fights them outside the campus. Karin refers to him as "Mr. Glasses Man" (meganekko), "Four eyes-san" or "Glasses Guy". His only true relative is his twin sister Kirika, but he does have another "sister" by the name of Himeka. In the anime, he is a running gag character; often leaving before ever winning and revealing his plot to Karin and the others while they didn't know, thinking they did. His ring has the powers of the god Ares. Later in the series, his ring is destroyed by Kazune. He then gets possessed by his father, Kirihiko, by the Zeus ring he wore after his broke, but in the end Karin and Kazune saved him.(episode 26) He then returns in Chu. Now, with the other Himeka, he is trying to create a new Zeus ring using the 'seed of chaos',in order to save the future Kirika who is sick. To do that, he has to revive his father, whom currently resides within Kuga Jin.

Michiru or Micchi is a fellow student of Karin and at one time lived with her, Kazune and Himeka. He was from England. When he was little, he was involved in an accident that killed his parents and crushed his left eye beyond repair, and almost died. But Kazuto made an eye for Michiru, and saved his life. Since he was in the hospital for a year, he is a year older than Karin, Kazune, and Himeka. Michiru shares a close bond to Kazune, because he first thought of him as Kazuto, and still respects Kazune. In the manga, Michiru's friend Ami brought a notebook containing information about Himeka for Kazune to read. Michiru is a bit a pervert around Karin, and in the manga, he stole Karin's first kiss. In Chu, his transformation is the god Neptune .