Keiko Agena (pronounced KAY-koh ah-GE-nah) was born in Honolulu, Hawaii. She is Japanese American. She began theatre acting at the age of ten. Agena has two cats. She has attended Mid Pacific Institute on the island of O ahu and Whitman College for one year as a drama major. She enjoys riding her motorcycle around Los Angeles and participating in an Asian-American theatre company called hereandnow. Agena married Shin Kawasaki in a helicopter over Las Vegas, NV on December 19, 2005.

Agena is known for her role in the television series Gilmore Girls, where she plays Lane Kim, a young Korean-American woman who is the best friend of one of the lead characters. Agena also appeared in the television series Felicity and was a recipient of the Best Female Actor prize in the Ammy Awards, which honor Asian and Asian-American achievement in film or television. She also provided the voice of Yori in the Disney cartoon series Kim Possible in seasons 2, 3 and 4 of the show. Also, Agena played Jun Ni in the movie Hair Show starring Mo'Nique. She recently guest starred on Private Practice