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Mann was born in San Francisco, California. She started out doing commercials at 17 years old, and beat 500 other actresses in an open audition for her role in The Cable Guy. She has starred in films such as George of the Jungle, Big Daddy, The 40 Year-Old Virgin and Knocked Up.

Mann is married to writer-director Judd Apatow, with whom she has two daughters, Iris and Maude. She met Apatow on the set of The Cable Guy (1996), which he produced.

• Funny People (2009) ... Laura
• I Love You Phillip Morris (2009) ... TBA
• Shorts (2009) ... Mom Thompson
• 17 Again(2009) .... Scarlett
• Drillbit Taylor (2008).... Lisa
• Knocked Up (2007) .... Debbie
• The 40 Year Old Virgin (2005) .... Nicky
• Stealing Harvard (2002) .... Elaine Warner
• Orange County(2002) .... Krista
• Perfume(2001) .... Camille
• Timecode(2000) .... Cherine
• Freaks and Geeks (2000) .... Miss Foote
• Big Daddy(1999).... Corinne Maloney
• George of the Jungle(1997) .... Ursula Stanhope
• Cosas que nunca te dije (1996) .... Laurie
• Last Man Standing(1996) .... Wanda
• She's the One(1996) .... Connie
• The Cable Guy (1996) .... Robin Harris
• Bottle Rocket(1996) (uncredited) .... Sorority Girl
• Birdland(1994) .... Nurse Mary (unknown episodes)
• Virgin High(1991) .... 'Squiggle' Girl