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Set at Woodrow Wilson High School in Seattle, Washington, Life As We Know Its lead was Dino Whitman (Sean Faris), a star ice hockey player. He had an uneasy relationship with his girlfriend, Jackie Bradford (Missy Peregrym), a soccer player. Jackie's best friend was Sue Miller (Jessica Lucas), a very competitive academic star. His best friends were Ben Connor (Jon Foster), who was carrying on an affair with a teacher, Monica Young (Marguerite Moreau); and Jonathan Fields (Chris Lowell), a nervous soul, especially about his girlfriend, Deborah Tynan (Kelly Osbourne). Jonathan was made even more nervous by Deborah's mother Mia (Sarah Strange), a nurse, sitting him down for a frank and graphic discussion about sex and its consequences.

Dino's parents' marriage fell apart after his mother had an affair with his hockey coach. His father, Michael, was played by D. B. Sweeney and his mother, Annie, was played by Lisa Darr. Coach Dave Scott was played by Martin Cummins.

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