It was created by Jody Schaeffer and George Krstic. Its opening song is "Megas XLR Theme (Chicks Dig Giant Robots)" by Ragtime Revolutionaries (now Deathwish Nine) (as listed in the credits). It is one of four animated series in which voice-actors Wendee Lee and Steven Jay Blum play teammates; the others are Cowboy Bebop (where Lee and Blum play Bebop crew members Faye Valentine and Spike Spiegel respectively), The Big O (where they play Angel and Roger Smith), and Rurouni Kenshin (as Shishio Makoto and Komogata Yumi).

Originally entitled Lowbrow, the pilot episode was shown during Cartoon Network's 2002 Summerfest, wherein eight original Cartoon Cartoon pilots were shown. As it was chosen as the most popular among viewers, Lowbrow was greenlit and became Megas XLR. After being delayed from its original debut in December 2003, Megas XLR finally debuted on Toonami in May 1, 2004 and was cancelled on April 26, 2005. Before and since the show being cancelled, characters have appeared in Cartoon Network's branding in both 2D and 3D CGI form. Megas XLR is now in comic form in the pages of DC Comics' Cartoon Network Action Pack, with the stories written by its co-creator George Krstic.

• Official UK Website
• Super Cartoon Network
• Official site at Cartoon Network (USA)