William Lee (Burroughs's pseudonym for his first novel, Junky) is an exterminator who finds that his wife is stealing his insecticide for recreational purposes. When Lee is arrested by the police, he believes himself hallucinating because of bug powder exposure. Lee believes himself a secret agent, and Lee's controller (a giant bug) assigns him the mission of killing his wife, Joan Lee, who is, according to the bug, an agent of an organization called Interzone Incorporated. Dismissing the bug and its instructions, Lee returns home to find his wife sleeping with Hank, one of his writer friends. He soon shoots her while performing a William Tell routine. Having "accomplished" his "mission", Lee flees to Interzone, where the Interzone Incorporated organization is based, and spends his time writing reports on his mission, which become the book Naked Lunch. While in Interzone, the typewriters Lee uses are themselves living creatures, usually giving Lee advice on his mission. Clark Nova, one of Lee's typewriters, tells him to find Doctor Benway, by means of seducing Joan Frost who is a doppelgänger of his dead wife, Joan Lee. After finding out that Doctor Benway is the head of a drug manufacturing ring, producing "the black meat", Lee completes his report and flees Interzone to Annexia with Joan Frost. Upon meeting the Annexian border patrol, to prove that he is a writer as he claims, he shoots Joan Frost in the head, in the same manner that he shot his late wife, Joan Lee. After seeing this, the border patrol welcomes Lee to Annexia.

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