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The series stars Loken as Jane Vasco[3], the titular character. She begins as a DEA agent, where in the course of her work she encounters Andre McBride (Rob Stewart), who is the leader of a team of agents working for an unspecified government agency. The team is based in a disused subway station named Deckard Street. She is forced to join the team after she probes "too far" into their operations. It is then revealed that the team's mission is to identify and neutralize "neuros" — "neurological aberrants" — human mutants with supernormal mental powers. Dialogue in the pilot states there are dozens of variations, and the reasons neuros use their abilities vary. It is then theorized that the aberrations interfere with the brain's ability to distinguish right from wrong.

During the pilot episode, Vasco discovers that she, too, has superhuman abilities — supernormal recuperative powers bordering on invulnerability. This is realized when she is pushed through a forty story window to her apparent death, only to later revive and then recover completely. However, she still feels the pain of her injuries before they heal. The team's doctor, Seth Carpenter, identifies her abilities as not like those of the neuros they track, but "something else."

• Painkiller Jane - Official Site at SciFi.com
• PKJ Files
• Painkiller Jane: TV Showguide at TVGuide.com

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