Airing at 3:00 a.m. ET on weekdays with repeats on weekends at 12:00 a.m. ET, the show covers a variety of topics, including news, entertainment, sports, and gossip. It is hosted by former Maxim UK editor Greg Gutfeld. The show features a round table of panelists, as well as guests linked by satellite. Bill Schulz appears as a regular panelist, while Andrew Levy acts as the show's primary ombudsman during the segment Halftime Report w/ Andy Levy. Comedienne Michelle Collins (of VH1's Best Week Ever blog) works as the substitute ombudswoman on days when Levy is unavailable or in the main studio. Fox News anchor Patti Ann Brown has also worked as a substitute ombudswoman; Ron Geraci has also worked as a substitute ombudsman, Collins has also substituted for Gutfeld as host. Rachel Marsden was a regular panelist on the show until May 2007.

Jackie Gutfeld ("Mrs. Gutfeld," Greg's mother) serves as the show's "senior correspondent." Michael Baden, a forensic pathologist, is the "death correspondent" of the show, having appeared multiple times to comment on news stories involving bodies or death. The segment is called "Master Baden." Tracey Westmoreland is the show's night life correspondent. Joe Francis was the show's "jailhouse correspondent" when he was serving time in prison and is now the show's "political correspondent." Janine Driver is the show's "Body language educator". Joshua McCarroll is the show's guest booker/"Matthew McConaughey correspond-aughey". Luke Campbell is the show's "Parental Advisory correspondent" and answers viewer email about parenting. Rep Thaddeus McCotter is the show's "congressional correspondent". Mark Prindle appears on the show to cover music news. Recently, the show's newest regular panelist has been a puppet, "Pinch", a New York Times Correspondent who is a caricature of the "elite media," and is a somewhat crude puppet made from a stack of New York Times papers (and is often insinuated to be the New York Times itself, rather than just a correspondent). The puppet is voiced by Bill Schultz, who also operates the mouth movements by pulling a string atop the puppet. The show's mascots are 'Unicorn Jones' and 'Fluffy McNutter', a cat-dog hybrid created by Gutfeld, based on a widely circulated image from the internet..

The show begins with Gutfeld's introduction of his guests, usually with either couched or explicit sexual inferences about each of them, often double entendres. The show is peppered with such inferences, sometimes including obscene imagery. Greg Gutfeld, with advisory from Bill Schulz and Andy Levy, writes the daily content.

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