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Merkerson made her television debut as Reba the Mail Lady on Pee-wee's Playhouse. "It was one of those wild things where I went to audition. And I thought I was funny and the person I auditioned for didn't, and so I had blown the job and I guess weeks later they got new casting people," Merkerson discussed on the NPR program, Tell Me More. "I didn't know who Pee-wee Herman was, so if, you know, for fans of the show, if they watch like the first episode that I ever did, I think it was a big party and he just kept making me laugh because I had never seen the character before. And the director was angry and he was like how can we get through this scene? And I said I have to look at the plate. So the entire plate he's serving hors d'oeuvre, I'm looking at the plate, and we're still good buddies. He still, to this day, knows how to make me laugh like no one else. Paul Reubens."[6] Merkerson also has appeared on The Cosby Show, among other series. [2] Her single most important television appearance may have been in the first-season Law and Order episode "Mushrooms", in which she portrayed the grief-stricken mother of an 11-month-old boy who is shot accidentally. Her performance was not only memorable to the audience during that key first season, but also impressed the producers enough to select Merkerson to replace Dann Florek as detective squad chief in the series' fourth season. Merkerson was nominated for a Tony Award as Best Featured Actress in a Play for her performance as Berniece in August Wilson's Pulitzer Prize-winning play, The Piano Lesson and won an Obie Award in 1992 for her work in I'm Not Stupid.[2] Her screen credits include Jacob's Ladder, Loose Cannons, She's Gotta Have It and in James Cameron's Terminator 2: Judgment Day, in which she played the terrified wife of Joe Morton. In 2006, she won Golden Globe, Emmy and Screen Actors Guild awards for her performance in the television movie Lackawanna Blues, her first starring role.[2] In 2007, she starred on stage in Los Angeles in William Inge's Come Back, Little Sheba at the Kirk Douglas Theatre in the role made famous by Shirley Booth, and in January 2008 opened on Broadway in the production. For the revival of Come Back, Little Sheba, Merkerson earned her second Tony nomination. In November 2007, Merkerson appeared in a TV commercial for Coricidin HBP. Merkerson also appears in a series of commercials for uni-ball pens and identity theft, directed by Emmy nominee Brent Roske.

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