He has appeared on Seinfeld ("The Cigar Store Indian", 1993, and "The Pie", 1994), The West Wing (as a conspiracy theorist adamant about his belief that the White House has information about extraterrestrial activity), 3rd Rock from the Sun ("Jailhouse Dick", 1997, and "My Daddy's Little Girl", 1998), and The Drew Carey Show. He had a guest role on Bill Lawrence's sitcom Spin City as a city hall bureaucrat, similar to his role as Ted Buckland in Scrubs. He was also a regular on the short-lived sitcom Double Rush, starring Robert Pastorelli. He has a recurring role on Desperate Housewives as Bree and Rex's psychiatrist, who recently falls victim to a demented suitor of Bree's. Lloyd's character showed a surprising amount of compassion for the perpetrator, despite being on a hospital bed with a broken leg.

Lloyd is the nephew of Back to the Future star Christopher Lloyd and the son of actor Sam Lloyd, Sr.[1] He and Christopher Lloyd both guested on Malcolm in the Middle, Sam as a housing lawyer and Christopher as Hal's father.

Lloyd is also a singer with the a cappella group The Blanks[2], which has made many appearances in Scrubs under the name "The Worthless Peons" (also known as "Ted's Band"). He also plays the bass in the Beatles tribute group "The Butties". Judging by the way he holds a bass guitar in Scrubs episodes My Best Friend's Wedding and air guitar in My Half-Acre it is assumed that he is left-handed.