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Mike Jon Favreau has just broken off a very long-term relationship in New York, and moves to LA to become a comedy star. He's lonely and his loneliness is bringing his buddies down. Mike's ultra-hip best friend, Trent Vince Vaughn, tries to get Mike to move on with life, but Mike is stuck in a rut. Bent on getting Mike back amongst the living, Trent and the crew drag Mike to a series of Hollywood parties, bars, and even on a spontaneous trip to Vegas.