The show focuses on a teenage girl, Alexandra "Alex" Mack, who becomes accidentally contaminated with an experimental chemical substance called GC-161. This results in certain powers, such as the ability to "zap" people and objects with an electrical charge, move objects by telekinesis, and change her shape into a silvery liquid. Throughout the series, the owners of the chemical plant which had been researching GC-161 continuously search for the local kid who was contaminated in order to conduct experiments, although their attempts are futile. Alex's best friend Ray, and eventually her sister, Annie, help her conceal the accident and her powers from her parents and others.

This is one of the few Nickelodeon shows to have something of a decisive conclusion [citation needed]. Nickelodeon rarely allows for series finales as they feel it makes it hard for them to rerun episodes indefinitely, and in any order they want, without confusing the viewer. As the storyline draws to a close, Alex's identity and powers are revealed to her enemies as well as her parents. This prompts her father to offer her a cure; Alex reacts with mixed feelings, though she accepts the vial anyway.

In the final scene, Annie indicates that she and everyone else believe Alex has already taken the cure, then walks away. The last shot shows Alex holding the full vial and smiling to herself, leaving it ambigious as to whether or not she intended to take it.

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