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Despite having four school-age children in the main roles, the show hardly (if ever) touches on aspects of school life (as Recess does), as stories nearly always begin on Friday afternoon and end on Sunday evening, with a few exceptions that cover the aftermath on Monday morning, usually only if the plot relates to homework or other school activities. Tino is the main character, and most episodes are told from his point of view. Tino often breaks the fourth wall and speaks directly to the viewer about what's going on à la Greek chorus.

The series, created by Doug Langdale, made its debut in 2000 as a part of Disney's One Saturday Morning on ABC and later on Disney's One Too on Sunday Mornings. Later it moved to cable channel Toon Disney and aired on The Disney Channel for a short time. In Canada, it is shown on the Family Channel. In the UK, Disney Channel began airing the show exclusively on Friday Afternoons, Saturdays and Sunday Mornings to fit in with the basic premise.

There are a handful of episodes that have never been screened in the US.

The show's title theme was written and performed by Wayne Brady.

TV Guide dubbed The Weekenders as "the show that killed Pokémon," because ABC stole the ratings when they aired it at 10:00 am - the same time Pokémon aired on Kids' WB.

The Weekenders began airing on Toon Disney again starting on May 13, 2008. It will be consistently aired every Tuesday from 2:30-4pm.