At the start of the series, a young girl named Ichigo Momomiya attends an endangered species exhibit with her 'crush' and future... More >
At the start of the series, a young girl named Ichigo Momomiya attends an endangered species exhibit with her 'crush' and future boyfriend, Masaya Aoyama. After an earthquake, Ichigo and four other girls are bathed in a strange light. A cat appears before Ichigo, then merges with her. The next day she begins acting like a cat and, after meeting Ryou Shirogane and Keiichiro Akasaka, learns that she was infused with the DNA of the Iriomote Cat. Ryou and Keiichiro explain that this allows her to transform into Mew Ichigo, a powerful heroic cat girl. She is ordered to defeat chimera animals—alien parasites—which infect animals and turn them into monsters. Ryou and Keiichiro instruct Ichigo to find the four other girls from the exhibit—the remaining Mew Mews. They are Mint Aizawa, a spoiled, wealthy girl who is infused with the genes of the Ultramarine Lorikeet; Lettuce Midorikawa, a meek but smart girl who endures constant bullying and absorbs the genes of the Finless Porpoise; young Pudding Fong, who receives the genes of the Golden Lion Tamarin; and Zakuro Fujiwara, a professional model infused with the genes of the Gray Wolf.

Masaya and Ichigo realize that the final mew aqua is inside his body. Deep Blue's spirit remerges, despite Masaya's attempts to regain control. Eventually, Deep Blue wins and claims to have destroyed Masaya completely. He goes to activate the mew aqua so he can destroy the Earth. Masaya's spirit emerges from his body, pulling Deep Blue's spirit out as well. He tells Ichigo to... More >
Masaya and Ichigo realize that the final mew aqua is inside his body. Deep Blue's spirit remerges, despite Masaya's attempts to regain control. Eventually, Deep Blue wins and claims to have destroyed Masaya completely. He goes to activate the mew aqua so he can destroy the Earth. Masaya's spirit emerges from his body, pulling Deep Blue's spirit out as well. He tells Ichigo to attack, knowing it will kill both of them. Before he dies, he tells Ichigo he wanted to save the Earth and that he loves her. With Deep Blue's death, the mew aqua is released, healing the destroyed city, the Mew Mews' wounds, and reviving the dead aliens. Masaya's body is returned to normal. Unwilling to let him die, Ichigo kisses him and gives him all of her power. Masaya awakens to find Ichigo lying beside him, dead. The other Mew Mews teleport into the base and begin crying over her death. They suddenly return to their normal forms as the base begins to fall apart. Kish appears with the last of the mew aqua. Pie and Tart also come and they thank the girls before teleporting them safely to the ground. The three aliens destroy the base to prevent it from falling on the city, then leave to return to their own world. Masaya kisses Ichigo. She detransforms and wakes up, to everyone's delight. The girls believe that they have lost their powers permanently, but discover that they only faded temporarily and are told that they have a new enemy.