The show usually revolves around a person or group of people who come to a crossroad in their lives, such as a big problem or a tough decision. Then angels enter the scene, bringing messages directly from God and helping people in their problems. Monica, the main angel character, is always learning how to assist humans with their needs and questions.

In the series premiere, bold supervisor Tess (played by Gospel singer, actress and pastor Della Reese) guides Monica (played by Roma Downey) on her first assignment as a case worker after being promoted from search and rescue.

The series finale shows Monica, who is up for promotion, defending Zack, an innocent drifter accused of blowing up a school full of children. The prosecutor is actually the Devil, played by David Ogden Stiers. Despite Monica's best efforts, Zack is convicted.

Visiting him in the prison, Monica offers herself to be his guardian angel for the rest of his life, protecting him from the dangers of the federal prison.

Later the citizens find out the truth: it was the prosecutor who blew up the school and framed Zack. Monica makes the citizens see that there's still hope to rebuild the life in the town and helps them to free themselves of the anger.

Before Zack can be sent to jail, however, he disappears. Monica then finds out that Zack was actually God. Defending Him was a test, and she succeeds: according to His words, "Greater love hath no person nor angel than to give her life for another." This has been considered the most explicit Gospel message of all the series, since it almost directly quotes Jesus' words ("Greater love hath no man than this, that a man lay down his life for his friends.") in John 15:13. Monica earns her promotion, and Tess hands her the keys to the red Cadillac convertible that the pair had received as a thank-you gift in the series premiere.

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