Raised in Fort Worth, Texas, Miller became interested in acting when she was quite young. She attended a high school for the performing arts and landed a number of high-profile commercials while still in college.

On summer vacation in Los Angeles, she took a course in stand-up comedy and went on to perform at such well-known clubs as The Improv and The Comedy Store. Despite offers to go on tour with her stand-up routine, Miller decided to move to Los Angeles and pursue acting.

She's best known for her role as Original Cindy in Dark Angel (2000-2001). She hosted two game shows; one was Gladiators 2000, the other was the ill-fated Peer Pressure. She also hosted the short-lived One Saturday Morning on ABC. As of fall 2007, Miller is appearing in the television drama Reaper on The CW.