Welcome to the Captain is a comedy about a wildly eclectic group of people whose lives are intertwined through the place they all call home, a fabled Hollywood apartment building, El Capitan, which they've dubbed "The Captain." Josh (Fran Kranz) is a Hollywood whiz kid whose filmmaking career has hit a wall. Just when Josh is about to move back to New York, his accountant-to-the-stars best friend, Marty (Chris Klein), convinces him to move into his legendary apartment building.

Among the eccentric tenants are Uncle Saul (Emmy Award nominee Jeffrey Tambor), a former "Three's Company" writer who is the building's self-proclaimed expert on anything and everything; Charlene (Golden Globe Award winner Raquel Welch), the femme fatale who welcomes Josh in her own seductive style; Jesus (Al Madrigal), a gossipy doorman who knows all the residents' most tantalizing secrets and Astrid (Valerie Azlynn), a flighty, aspiring young actress. Josh is most taken with the earthy, beautiful Hope, (Joanna Garcia), an aspiring acupuncturist who enlists him as a practice patient.

The folklore of this fabled apartment building always continues to grow and, as each dweller quickly learns, the walls never stop talking.