The story centers around a space cargo transporter named James Links, his family, and their adventures in the Zone of the Enders universe.

The events of the story are set in motion when James is sent a mysterious Orbital Frame called Dolores (a.k.a ISIS) with instructions to deliver it to Earth and not to let anyone get ahold of it. During the series, James attempts to reconnect with his adult children, Leon and Noel, as well as search for his long-lost (and reportedly dead) wife Rachel. The intelligent, well-mannered and well-meaning, but somewhat awkward and naive Dolores accompanies him as many enemies attempt to stop him, manipulate him, or capture Dolores.