Is Zach and Miri the next 40 Year Old Virgin/Wedding Crashers?

And by that...I mean can it achieve the near-impossible of being a high-grossing R-rated comedy?

Everything that I have seen associated with it thus far is hilarious, including the banned poster, red band trailer (for mature viewers only) and now this non-banned poster displayed here, which I think is totally clever!

Who else is excited for this film?