Seems as though the episode did the trick, as West has since responded on his blog. Some choice quotes (replicated in Kayne's signature all-caps style):
"I JUST WANT TO BE A DOPER PERSON WHICH STARTS WITH ME NOT ALWAYS TELLING PEOPLE HOW DOPE I THINK I AM."
"I GOT A LONG ROAD AHEAD OF ME TO MAKE PEOPLE BELIEVE I'M NOT ACTUALLY A HUGE DOUCHE BUT I'M UP FOR THE CHALLENGE. I'M SURE THE WRITERS AT SOUTH PARK ARE REALLY NICE PEOPLE IN REAL LIFE."
So...has Kanye finally been humbled?
You can read his full blog post here.