The good news for fans of Chase (Jesse Spencer) and Cameron (Jennifer Morrison) is, Cameron doesn't die or anything of the sort, thus making a return in the future totally plausible. The bad news is, we can't really say when or even give House fans a definite yes as to whether or not she will return in the first place.
Spencer tells us that, essentially, we don't know anything at this point, except that she will really leave (categorically) House.
"It is open for her to come back at some point," he says. "But we don't know in what fashion that will be. That's what makes it exciting. The story line has been set up and right now it's just brewing there, but I don't know how it's going to end."
Yet House fans seem to ask why she has to take the bullet when it's obvious that it's Chase who's being consumed by guilt over the decision of sort of killing someone to hopefully save the lives of many others.
Spencer explains that Chase's weirdness will prompt Cameron into thinking that something is "obviously" wrong.
"She offers for her and Chase to leave and go somewhere. He accepts it [at first] and then realizes that he really can't go anywhere because it's just going to follow him everywhere he goes. That leads them to go their separate ways."
Will Chase ever be able to put some semblance of closure into the whole incident? No, in a nutshell, says Spencer, but that's not necessarily a bad thing. He adds that a trial for medical practice might even been necessary, just to help him get past this demon (and that's not just about the dictator, but the overall guilt that has consumed him).