This week's episode of Supernatural was all about guilty - something the Winchesters have in spade. Dean, in particular, has always felt tremendously guilty...for the people he couldn't save, or the loved ones who died in the line of duty, or, in particular, for failing his brother. The boys headed to Dearborn, Michigan to investigate a string of murders, only to figure out what the person doing the killing was an Egyptian god, Osiris. More specifically, he was setting up trials, where he would weigh the guilt of people and punish those who believed they had something to feel guilty for.
Osiris honed in on Dean, calling Jo's ghost as a witness. Sam stepped in to defend his brother, but Dean was prepared to die so that Sam didn't find out about Amy. Fortunately, Sam was able to kill Osiris just before Jo's ghost could kill Dean.
In the October 21 episode, Buffy alums Charisma Carpenter and James Marsters guest star as Maggie and Donald Stark. After Don cheated on her, Maggie decides to unleash her witchy powers on her unsuspecting down. Since these attacks result in numerous deaths, Sam and Dean investigate. Once they find the source of the problem, they track down Don to see if he can help stop his wife.