Kelly Ripa will be joined by Neil Patrick Harris at the 'Live! With Kelly' table for a week.
Harris will guest co-host the show for five days, Nov. 28 - Dec. 2.
The 'How I Met Your Mother' star will be the second guest co-host to join Ripa after Regis Philbin leaves the show Fri., Nov. 18. Harris will follow Jerry Seinfeld, who will co-host from Mon., Nov. 21 to Wed., Nov. 23.
When Kathie Lee Gifford left the series in 2000, the show followed a similar format of rotating guest co-hosts, auditioning for her replacement until Ripa became the permanent co-host in 2001.