When my friends first told me what House was about my reaction was "It's a show about what?!" Why would I want to watch a show about a narcissistic drug addict who is an asshole to everyone.. oh.. and he does medicine.
After watching the first episode I suddenly understood it, it's GREAT, I can confidently say that this is the best show on TV, it's a great mix of comedy and drama, it hooks you and you cannot stop.
I watched one episode and a month later I had watched the whole series up to current, and now I am spreading the goodness to every person I can. House is simply a phenomenon, you can't stop it!