There's been plenty of drama to keep us occupied in her absence, but with the second half of the season in full swing, Grey's Anatomy fans are wondering about Katherine Heigl.
What is her status? Is she ever returning to the show? When she is back, will she just leave at the end of the season? According to EW, she's due back on set later this month.
That means we probably won't see Izzie again until late April, and coincidentally, that's right around the time a new, special patient will check into Seattle Grace: Alex's brother.
Sources say Grey's Anatomy is currently casting the role of Karev's estranged sibling - the first member of the character's supposedly troubled family we will meet in six seasons.
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