To answer the question above, sadly...it seems 99% yes.
-The show has already been considered "in danger" and "on the bubble" since before this season premiered.
-Tyler Labine (Sock) has signed onto a FOX pilot (though of course, if Reaper were to be renewed, the pilot could be dropped).
-And the most damning: The series creator and executive producer have just signed a 2 year deal with 20th Century FOX TV, part of which calls for them to leave Reaper at the end of this season (which again, suggests they are confident it won't be renewed).
Sorry Reaper fans...