Buffy & Angel - Buffy the Vampire Slayer and Angel
I'd say that Buffy and Angel pretty much define the star-crossed lovers. After all, spoiler alert, after the two have sex for the first time and Angel experiences a moment of pure happiness, a gypsy curse is then broken, causing Angel to lose his soul. He then turns into the evil Angelus. Yikes! Have we mentioned that Buffy must also spoiler alert sacrifice Angel to save the world at the end of Season 2? We also all know that Angel eventually comes back from Hell, though when it becomes apparent that the whole Buffy/Angel thing won't ever really work, Angel skips off to LA...
Dan & Serena and Chuck & Blair - Gossip Girl
We believe that both of these couples are meant to be, yet somehow they are always fighting with one another, breaking up, getting back together, breaking up, not being able to tell the other one they love them, lying, cheating, sleeping with teachers, sleeping with hookers, need I go on?
Ted & Robin - How I Met Your Mother
Another spectacular example of the star-crossed pairing, as we know that Robin and Ted love one another (and are meant to be together), yet the show has told us from Day One that the two do not and cannot end up together! Why? Why? I still think that somehow they are in the end going to tell us it was all a big ruse and they were just kidding about that whole Aunt Robin thing...
Izzy & Denny - Grey's Anatomy
She's alive (we think, but who the hell knows what's up with Izzy these days) and he's dead, so I'd say that that would make soul mates Isobel Stevens (Katherine Heigl) and Denny Duquette (Jeffrey Dean Morgan) pretty damn star-crossed. Then again, maybe with all of these rumors, the two will soon be meeting once again up in heaven.
Clark & Lana - Smallville
We watched these two characters fall in love from the very beginning of Smallville and rooted for them and wanted them to end up together. Their chemistry was undeniable. Yet we also knew via the Superman mythology from the beginning that these two were never meant to be. Who saw Requiem? Case and point.
So...who are your favorite pairs of star-crossed TV lovers?