I loved this show because it was a different kind of vampire show and had an interesting take on vampirism in general. I also liked the idea that they showed how "normal" (god I hate that word) people react to vampires and tackled topics like racism and homophobia. The most significant characters to me were the always sassy Lafayette and the vampire newbie Jessica.
And of course it wouldn't have been the same without handsome Eric and bitchy Pam! I wasn't a big fan of the main characters Sookie and Bill but loved it for everything else.