e series follows the adventures of the high-tech submarine seaQuest operated by the United Earth Oceans Organization (UEO), a global federation of nations, similar to the United Nations, which was created following a major global conflict that occurred circa 2010. The seaQuest was built by NORPAC (a military organization mentioned in the pilot) and given to the UEO after its creation. The storyline begins in the year 2018, after mankind has exhausted almost all natural resources, except for the ones on the ocean floor. Many new colonies have been established there and it's the job of the seaQuest and its crew to protect them from hostile nonaligned nations and to aid in mediating disputes. Part of the original focus of seaQuest DSV also centered around the interpersonal relationships of the crew, such as Captain Bridger's, Lucas Wolenczak's, and Dr. Westphalen's loss of immediate family and their shared interest in science, as well as each other, and the "love-hate relationship" between Lieutenant Benjamin Krieg and Lieutenant Commander Katherine Hitchcock, recently divorced, now forced to serve together on the same ship.

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