Two single and extremely eccentric New Yorkers are subjected to constant interference when they begin dating, from their equally eccentric friends
Nate wakes up in Natalie's bed, and quickly gets out of there. He later tells Marni, and about a kiss shared between Nate & Natalie. Marni decides she needs to kiss a guy to be even, which leads to Nate and Marni "breaking up". However, Marni is reluctant to give up, and chases Nate down, who says his speech was only to say he is sick of Marni's behavior, and that they will be together forever.
In the pilot, Nate is set up to go on a blind date with Susan, only when he goes to pick her up, he picks up Marni, who was set to go on a different blind date. After talking through dinner, they realize they are perfect for each other, but also realize that they are on the wrong dates.