Adrienne asks Serena to help her end her life. Serena initially refuses, but later agrees that Adrienne is lucid enough to sign a DNR. Shortly after, Adrienne suffers a stroke and dies, leaving Serena devastated. Meanwhile, Adele struggles to balance her career and her coursework. Michael tries to extend his time at Holby, and he and Fleur work together on a double limb reattachment. After the successful operation, Michael ultimately decides to return to the US.