Descendants of the Looney Tunes, including Ace Bunny and Danger Duck, become superheroes, when the aftershock of an alien meteor grants them each with strange new powers, and battle adversaries in 2772.
After receiving a message containing clues on Tweetums' whereabouts, the Loonatics and Sylth Vester seek out where Tweetums is. Meanwhile, General Deuce and Optimatus begin their plans to conquer the universe. However, Deuce betrays Optimatus, who joins up with Zadavia and the Loonatics. During the final battle between Deuce and Ace, Ace banishes him to another universe. The episode ends with the Loonatics realizing they have graduated from merely protecting Acmetropolis, and are now protectors of the entire universe. The team decides to relocate their headquarters to Planet Blanc, which will allow them to instantly reach any troubled spot anywhere in space.
In the Loonatics Unleashed series premiere, the citizens of Acmetropolis are living through a heat wave when suddenly, temperatures drastically drop and the planet is in the grip of a sudden cold snap. Zadavia summons the Loonatics to investigate and they find a group of space Vikings are responsible for the deep freeze and must stop the Vikings from making the freeze permanent. The Loonatics are frozen by the vikings but Slam Tasmanian frees them.
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