Descendants of the Looney Tunes, including Ace Bunny and Danger Duck, become superheroes, when the aftershock of an alien meteor grants them each with strange new powers, and battle adversaries in 2772.
After receiving a message containing clues on Tweetums' whereabouts, the Loonatics and Sylth Vester seek out where Tweetums is. Meanwhile, General Deuce and Optimatus begin their plans to conquer the universe. However, Deuce betrays Optimatus, who joins up with Zadavia and the Loonatics. During the final battle between Deuce and Ace, Ace banishes him to another universe. The episode ends with the Loonatics realizing they have graduated from merely protecting Acmetropolis, and are now protectors of the entire universe. The team decides to relocate their headquarters to Planet Blanc, which will allow them to instantly reach any troubled spot anywhere in space.
Now that Optimatus is free, he alongside General Deuce and Rupes Oberon plan to use Planet Blanc's wormhole generator to take over the universe. Planet Blanc is said to be at the center of the universe, and that every point in the universe can be instantly traveled to with ease from it. The Royal Tweetums contacts the Loonatics for help. It turns out that Tweetums evaded capture. The Loonatics must find him before Optimatus does, but not without help from an old enemy.
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