During the next meeting between Hashirama and Madara, the two try to warn each other that their families are after them. But when Butsuma and Tobirama arrive at the same time as Madara's brother Izuna and their father Tajima and the confrontation leads to Izuna almost being killed, Madara accepts the reality they live in and agrees to continue fighting against the Senju. As the years pass, Hashirama and Madara become the leaders of their respective clans as the conflict between their families continues with many casualties. During one such battle, Tobirama fatally wounds Izuna.