Dr. Sam Stewart runs a remote medical clinic on Hope Island in the Great Barrier Reef. She's a GP, but in her spare time she and her colleague, Pharmacologist, Gus Cochrane, spend their spare moments chasing venomous creatures to discover the secrets of venom. When the mainland University Hospital wants more venom for research, Sam pleads with her ex-husband (and boss), Andrew, to send her a new doctor to assist her in the running of her remote Hope Island Clinic.