The Stooges operate a local drugstore whose landlord, the cantankerous Amos Flint (Emil Sitka), informs them their lease is about to expire. Larry protests that the trio have had their establishment for a decade, and do not want to leave. As the four bicker, Flint's elderly wife Cerina (Christine McIntyre) enters the store, only to be berated by Flint for being an old hag. "25 years is enough," he coldly confirms. After he storms off, the boys take to the frail Cerina, who begins to weep that ever since she lost her beauty, Amos had threatened to leave. Both saddened and incensed, the Stooges offer Cerina their spare room in the back. Shemp, seeing this, hatches a plan to invent a "Fountain of Youth" to restore Cerina to her stunning beauty. Deeming the idea "tremendous, colossal and putrid," the Stooges flee to their pharmaceutical lab and mix together a powerful serum.